Projects
Acute leukemias
Transformation in leukemia/lymphoma
Understanding the pathogenesis of acute leukemias continues to be a challenge. We tackle this area of medicine with conventional and cutting edge scientific approaches.


The molecular transformation of hematolymphoid neoplasms to aggressive forms is critical to understand so that we may 1) detect it, 2) prevent it, 3) predict it, 4) and treat it. Genomic approaches have been particularly insightful and are ongoing.


T-cell development
Reactive vs neoplastic
The distinction between reactive conditions and neoplastic ones is not always clear. Efforts to understand unusual reactive processes are informative in understanding cancer as well.



T-cell development still confounds researchers. Recently we have been characterizing indolent T-lymphoblastic proliferations which are proliferations of immature thymic T-cells outside of the thymus. These unusual processes have informed us about immature thymic T-cell growth and development.


Diagnostic Dilemmas
The diagnosis and subtyping of hematolymphoid neoplasms constantly changing. Developing new diagnostic categories that are important to patient care are also critical areas of exploration. 


Inflammation in neoplastic and non-neoplastic pathology
Inflammation is common in all malignancies. How inflammatory cells shape the process of malignancy is still poorly understood, but significant headway has been made in recent years.